Back to Work
If you haven't, you really should check out the great Back to Work podcast with Merlin Mann of 43 Folders fame.
Don't let the name fool you. It's as hillarious as it is insightful.
Start with the earlier episodes, as the more recent ones are packed with inside jokes and get a little...silly. If you're in your '20s and feeling lost, episode 7, "Vocational Wheel" will be of particular interest to you.
If you're a new listener, Merlin compiled a starter pack to keep you from getting lost.